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Abstract #0182

Anatomic alterations in amygdala subregions in medication-free patients with obsessive-compulsive disorder

Lianqing Zhang1, Xinyu Hu1, Hailong Li1, Shi Tang1, Lu Lu1, Xuan Bu1, Xiaoxiao Hu1, Yingxue Gao1, Yanlin Wang1, yanchun Yang2, John A. Sweeney1,3, Qiyong Gong1, and Xiaoqi Huang1

1Department of Radiology, Huaxi MR Research Center (HMRRC), Sichuan University, Chengdu, China, 2Department of Psychiatry, Sichuan University, Chengdu, China, 3Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States

Most previous human neuroimaging studies measured the volume of amygdala as a whole, however, the amygdala consists of several functionally distinct subnuclei. Recent advances in structural MR image segmentation technique have made it possible to study amygdala subnuclei volumes with a robust, automatic approach using a Bayesian inference-based atlas building algorithm. Using this algorithm, we for the first time provide a distinctive profile of amygdala subnuclei volume abnormality in a relatively large sample of drug-free obsessive-compulsive disorder patients, and provide an insight that these subnuclei contribute to different aspect of neuropathology in the disorder.

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