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Abstract #0189

Thalamic Substructures in Alcoholism: Volume Deficits and Functional Correlates

Natalie Zahr1,2, Kilian Marie Pohl1, and Manoj Saranathan3

1Neuroscience, SRI International, Menlo Park, CA, United States, 2Stanford University, Stanford, CA, United States, 3Department of Medical Imaging, The University of Arizona Health Sciences, Tucson, AZ, United States

Volumes of 5 thalamic substructures—mediodorsal (MD), anterior (AV), ventral lateral posterior (VLp), ventral posterior lateral (VPl), pulvinar (Pul))—were quantified using a novel automated segmentation algorithm in 40 individuals with Alcohol Use Disorder (AUD) and 60 controls (Con). Multiple regressions on supratentorial-volume-corrected measures revealed that volumes of AV, VLp, VPl, and Pul were smaller with older age, and volumes of AV, VLp, Pul, and MD were smaller in the AUD than Con group. Functional ramifications of thalamic substructures indicated relations between back pain and smaller Pul and VLp volumes, and poor ataxia scores with smaller VPI volumes.

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