Abstract #0188

PET derived Raphe Nuclei [11C]-CUMI binding potential is associated with MR derived diffusion entropy in the frontal and temporal lobes

Mario Serrano-Sosa¹, Karl Spuhler¹, Christine DeLorenzo², Ramin Parsey², and Chuan Huang^2,3

¹Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ²Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, ³Radiology, Stony Brook Radiology, Stony Brook, NY, United States

Using a new DTI processing technique, named diffusion entropy, and dynamic PET data we observed a statistically significant inverse correlation between diffusion entropy and [11C]-CUMI binding potential (BP_F) in a dataset with bipolar, major depressive disorder patients and controls. This newfound analysis can give rise to further understanding the pathophysiology that undermines psychiatric diseases and, also, a non-invasive, non-ionizing radiation procedure to estimate [11C]-CUMI BP_F.

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