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Abstract #0188

PET derived Raphe Nuclei [11C]-CUMI binding potential is associated with MR derived diffusion entropy in the frontal and temporal lobes

Mario Serrano-Sosa1, Karl Spuhler1, Christine DeLorenzo2, Ramin Parsey2, and Chuan Huang2,3

1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, 3Radiology, Stony Brook Radiology, Stony Brook, NY, United States

Using a new DTI processing technique, named diffusion entropy, and dynamic PET data we observed a statistically significant inverse correlation between diffusion entropy and [11C]-CUMI binding potential (BPF) in a dataset with bipolar, major depressive disorder patients and controls. This newfound analysis can give rise to further understanding the pathophysiology that undermines psychiatric diseases and, also, a non-invasive, non-ionizing radiation procedure to estimate [11C]-CUMI BPF.

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