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Abstract #0187

Neural Correlates of Rumination in Normal and Major Depressive Disorder: A Brain Network Analysis

Yael Jacob1, Laurel Morris1, Kuang-Han Huang1, Molly Schneider1, Gaurav Verma1, James Murrough1, and Priti Balchandani1

1Icahn School of Medicine at Mount Sinai, New York, NY, United States

Major depressive disorder (MDD) patients exhibit higher rumination levels; repetitive thinking and focus on negative states. Rumination is known to be associated with brain cortical midline and limbic structures, yet, the underlying brain network topological organization remains unclear. Implementing a graph-theory analysis we tested whether whole brain network connectivity hierarchies during fMRI resting state are associated with rumination. We found a significant correlation between right caudal anterior cingulate (cACC) connectivity strength and subjective rumination tendency. This result emphasize the cACC impact during self-reflective processing, which might serve as biomarker for clinical diagnosis.

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