Major depressive disorder (MDD) patients exhibit higher rumination levels; repetitive thinking and focus on negative states. Rumination is known to be associated with brain cortical midline and limbic structures, yet, the underlying brain network topological organization remains unclear. Implementing a graph-theory analysis we tested whether whole brain network connectivity hierarchies during fMRI resting state are associated with rumination. We found a significant correlation between right caudal anterior cingulate (cACC) connectivity strength and subjective rumination tendency. This result emphasize the cACC impact during self-reflective processing, which might serve as biomarker for clinical diagnosis.
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