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Abstract #0186

Discrete Regions of Gray Matter Loss Underlie Major Depressive Disorder: A Replication and Expanded Investigation

Sarah C Hellewell1, Thomas Welton1, Jerome J Maller1,2, Matthew Lyon1, Mayuresh S Korgaonkar3, Stephen H Koslow4, Leanne M Williams5, Evian Gordon1,6, A John Rush7,8, and Stuart M Grieve1,9

1Sydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Sydney, Australia, 2General Electric Healthcare, Melbourne, Australia, 3The Brain Dynamics Centre, Westmead Millennium Institute and Sydney Medical School, Sydney, Australia, 4Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States, 5Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 6Brain Resource Ltd, Sydney, Australia, 7Duke-National University of Singapore, Singapore, Singapore, 8Department of Psychiatry, Duke Medical School, Durham, NC, United States, 9Department of Radiology, Royal Prince Alfred Hospital, Sydney, Australia

The aims of this study were to construct a biomarker based on anatomical regions of profoundly reduced gray matter volume in subjects with major depressive disorder. Our biomarker successfully discriminated MDD subjects from controls at an accuracy of 73%, suggesting a possible role for network measurements of GM susceptibility in MDD.

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