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Abstract #0185

Emotion Self-Regulation Training with Simultaneous Real-Time fMRI and EEG Neurofeedback in Major Depression

Vadim Zotev1, Ahmad Mayeli1,2, Masaya Misaki1, and Jerzy Bodurka1,3

1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States, 3Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

We report a study of emotion self-regulation training in patients with major depressive disorder (MDD) using simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf). Emotion-relevant target nf measures included fMRI activities of the left amygdala and left rACC, and frontal EEG asymmetries in the alpha and high-beta bands. MDD patients successfully learned to upregulate all four measures simultaneously using rtfMRI-EEG-nf during a happy emotion induction task. EEG-fMRI data analyses provided new insights into mechanisms of rtfMRI-EEG-nf. These findings may lead to development of more efficient neurotherapies for MDD.

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