Abstract #0184

Imaging hippocampal glutamate alterations in a 22q11.2 deletion syndrome mouse model of schizophrenia

Puneet Bagga¹, David Roalf², Hari Hariharan¹, Anderson Stewart², Douglas Coulter³, Raquel Gur², and Ravinder Reddy¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States

Schizophrenia (SZ) is a common, severe mental illness caused by neurobiological disturbances in glutamate and dopamine. Glutamate is the major excitatory neurotransmitter in the brain and can be detected using MR spectroscopy and glutamate-weighted chemical exchange saturation transfer (GluCEST) MRI. In this study, we performed high-resolution GluCEST MRI in the 22q11.2 deletion syndrome (22q11.2DS) mouse model of SZ to evaluate glutamatergic alterations in the dorsal and ventral hippocampus. The GluCEST contrast was found to be lower in the hippocampus of 22q11.2DS mice compared to that in the age-matched control mice indicating the lower hippocampal glutamate level in the preclinical model of SZ.

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