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Abstract #0198

The effects of neoadjuvant chemotherapy on axillary lymph node volume and compacity in breast cancer patients: an MRI study

Renee Faith Cattell1, Krupal Patel1, Thomas Ren1, James Kang1, Pauline Huang1, Jason Ha1, Ashima Muttreja1, Jules Cohen1, Haifang Li1, Lea Baer1, Cliff Bernstein1, Sean Clouston1, Roxanne Palermo1, and Timothy Duong1

1Stony Brook University, Stony Brook, NY, United States

Axillary lymph node involvement in breast cancer is associated with higher risk of distant metastasis and recurrence. This study evaluated whether MRI can be used to longitudinally monitor effects of neoadjuvant chemotherapy on axillary lymph nodes in situ. Nodal volume and compacity were analyzed with respect to treatment responders and non-responders. Comparisons with unaffected nodes were made. Neoadjuvant chemotherapy significantly reduced nodal volume of the affected nodes in both responders and non-responders. Nodal volumes of the responders normalized whereas those of the partial-responders did not normalize completely. This approach may prove useful for monitoring cancer treatment effects on nodal morphology.

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