Abstract #0199

Lymphovascular invasion correlates with elevated tumor pressure as quantified by MR Elastography: initial results from a breast cancer trial

Daniel Fovargue¹, Sweta Sethi^2,3, Jack Lee¹, Marco Fiorito¹, Adela Capilnasiu¹, Stefan Hoelzl¹, Jurgen Henk Runge^1,4, Jose de Arcos¹, Keshthra Satchithananda⁵, Arnie Purushotham³, David Nordsletten^1,6, and Ralph Sinkus^1,7

¹School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ²Guy's and St.Thomas' NHS Foundation Trust, London, United Kingdom, ³Division of Cancer Studies, King's College London, London, United Kingdom, ⁴Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, ⁵King's College Hospital, London, United Kingdom, ⁶Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ⁷U1148, INSERM, Paris, France

Gauging metastatic propensity is crucial as it impacts decision making in oncology (e.g. whether a patient should receive surgery immediately or neoadjuvant chemotherapy). Interstitial fluid pressure (IFP) is known to correlate with microvascular invasion, a proxy for metastatic potential. However, no current imaging biomarkers correlate with this. We present a method to noninvasively calculate a total tumor pressure (which IFP contributes to). The method reconstructs pressure via nonlinear biomechanics and MR Elastography and is validated in simulations and phantoms. Elevated pressure values from a cohort of 16 breast cancer patients correlate with lymphovascular invasion possibly providing a much sought-after biomarker.

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