Meeting Banner
Abstract #0224

Application of an Extended Stretched-Exponential Model for Morphometric Analysis of Accelerated Diffusion-weighted 129Xe MRI of the Rat Lung

Alexei Ouriadov1, Matthew S Fox2, Andras A Lindenmaier3,4, Elaine Stirrat3, Grace Parraga1,5,6, and Giles Santyr3,4

1Robarts Research Institute, London, ON, Canada, 2Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, 3Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada, 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 5Department of Medical Biophysics, Western University, London, ON, Canada, 6Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Hyperpolarized 129Xe pulmonary MRI is poised for clinical translation due in part to the clinical-relevance of 129Xe MRI biomarkers of lung disease. A rapid multi-b diffusion-weighted 129Xe MRI requires for clinical morphometry due to the challenges in acquiring a fully-sampled dataset during the relatively short 10-16sec breath-holds. Therefore, in this proof-of-concept evaluation, our objective was to measure morphometry estimates in a small group of control-rats as well as rats with early stage radiation-induced-lung-injury, and compare the stretched-exponential-model based morphometry estimates for three different cases: 1) fully-sampled k-space 2) 85% retrospectively under-sampled k-space, (acceleration factor (AF)=7), and 3) 90% retrospectively under-sampled (AF=10) k-space.

This abstract and the presentation materials are available to members only; a login is required.

Join Here