Abstract #0224

Application of an Extended Stretched-Exponential Model for Morphometric Analysis of Accelerated Diffusion-weighted 129Xe MRI of the Rat Lung

Alexei Ouriadov¹, Matthew S Fox², Andras A Lindenmaier^3,4, Elaine Stirrat³, Grace Parraga^1,5,6, and Giles Santyr^3,4

¹Robarts Research Institute, London, ON, Canada, ²Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, ³Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Department of Medical Biophysics, Western University, London, ON, Canada, ⁶Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Hyperpolarized ¹²⁹Xe pulmonary MRI is poised for clinical translation due in part to the clinical-relevance of 129Xe MRI biomarkers of lung disease. A rapid multi-b diffusion-weighted ¹²⁹Xe MRI requires for clinical morphometry due to the challenges in acquiring a fully-sampled dataset during the relatively short 10-16sec breath-holds. Therefore, in this proof-of-concept evaluation, our objective was to measure morphometry estimates in a small group of control-rats as well as rats with early stage radiation-induced-lung-injury, and compare the stretched-exponential-model based morphometry estimates for three different cases: 1) fully-sampled k-space 2) 85% retrospectively under-sampled k-space, (acceleration factor (AF)=7), and 3) 90% retrospectively under-sampled (AF=10) k-space.

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