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Abstract #0223

Is spherical diffusion encoding rotation invariant? An investigation of diffusion time-dependence in the healthy brain

Filip Szczepankiewicz1,2, Samo Lasic3, Markus Nilsson4, Henrik Lundell5, Carl-Fredrik Westin1,2, and Daniel Topgaard6

1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Random Walk Imaging AB, Lund, Sweden, 4Clinical Sciences Lund, Lund University, Lund, Sweden, 55. Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 6Physical Chemistry, Lund University, Lund, Sweden

Recent advances in diffusion weighted MRI have reignited interest in spherical (or isotropic) diffusion encoding. For such encoding to reach high efficiency (minimal echo time), the gradient waveforms have irregular shapes, by design. As such, they lack a well-defined diffusion time and can even be spectrally anisotropic. Most analysis methods based on such encoding assume that diffusion is multi-Gaussian, i.e., that the diffusion is not time-dependent. Since this is a central assumption, we investigate if spherical diffusion encoding is indeed rotation invariant, or if the diffusion time anisotropy has a discernible effect on the diffusion weighted signal in healthy brain.

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