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Abstract #0236

In-vivo diffusion-fMRI using Incomplete Initial Nutation Diffusion Imaging (INDI)

Daniel Nunes1 and Noam Shemesh2

1Champalimaud Research, Champalimaud Centre for the Unkown, Lisbon, Portugal, 2Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal

Diffusion functional-MRI (dfMRI) is thought to capture microstructural changes associated with neural activity. The water apparent diffusion coefficient decrease observed upon neuronal activity is hypothesized to be cell-swelling dependent. Yet, one of the confounding factors for dfMRI is that zero and nonzero b-values need to be acquired to deliver accurate changes in diffusivity and those images are typically separated by at least one repetition time. Incomplete initial Nutation Diffusion Imaging (INDI) was proposed as a method to acquire two images with different diffusion-weighting with separation of <50ms. Here, we performed INDI-fMRI experiments to report mean diffusivity changes using forepaw-stimulated rats.

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