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Abstract #0237

Robustness of PSIR segmentation and R1 mapping at 7T: a travelling head study

Olivier E. Mougin1, William T Clarke2, Ian Driver3, Catarina Rua4, Andrew T Morgan5, Susan Francis1, Keith Muir5, Adrian Carpenter4, Chris Rodgers4, Richard Wise3, David Porter5, Stuart Clare2, and Richard E. Bowtell1

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Nuffield Department of Clinical Neurosciences, University of Oxford, Wellcome Centre for Integrative Neuroimaging (FMRIB), Oxford, United Kingdom, 3School of Psychology, Cardiff University, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 4Department of Clinical Neurosciences, University of Cambridge, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, 5University of Glasgow, Imaging Centre of Excellence, Glasgow, United Kingdom

Ultra-high magnetic field (7T) MRI scanners can provide high spatial resolution images and excellent contrast for classifying brain tissue, but robustness of tissue segmentation and R1 quantification across sites is key for the implementation of multi-site studies. Here, we present a subset of the main UK7T travelling-head study, focusing on harmonized T1-weighted images (0.7mm3 isotropic resolution) acquired on six subjects across three 7T sites, with five repeats at one site. The aim of this study is to assess the harmonisation and robustness of the MP2RAGE sequence and PSIR reconstruction across sites, by focusing on segmentation reproducibility and T1 estimation.

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