Abstract #0237

Robustness of PSIR segmentation and R1 mapping at 7T: a travelling head study

Olivier E. Mougin¹, William T Clarke², Ian Driver³, Catarina Rua⁴, Andrew T Morgan⁵, Susan Francis¹, Keith Muir⁵, Adrian Carpenter⁴, Chris Rodgers⁴, Richard Wise³, David Porter⁵, Stuart Clare², and Richard E. Bowtell¹

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²Nuffield Department of Clinical Neurosciences, University of Oxford, Wellcome Centre for Integrative Neuroimaging (FMRIB), Oxford, United Kingdom, ³School of Psychology, Cardiff University, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, ⁴Department of Clinical Neurosciences, University of Cambridge, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, ⁵University of Glasgow, Imaging Centre of Excellence, Glasgow, United Kingdom

Ultra-high magnetic field (7T) MRI scanners can provide high spatial resolution images and excellent contrast for classifying brain tissue, but robustness of tissue segmentation and R₁ quantification across sites is key for the implementation of multi-site studies. Here, we present a subset of the main UK7T travelling-head study, focusing on harmonized T₁-weighted images (0.7mm³ isotropic resolution) acquired on six subjects across three 7T sites, with five repeats at one site. The aim of this study is to assess the harmonisation and robustness of the MP₂RAGE sequence and PSIR reconstruction across sites, by focusing on segmentation reproducibility and T₁ estimation.

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