Cerebrovascular reactivity (CVR) has recently become a focus for many labs. However, CVR calculation has always required at least some degree of manual intervention. Therefore, our lab has developed CVR-MRICloud, a free, online, fully automated CVR processing pipeline. Our pipeline returns CVR maps, relative bolus arrival time maps, and region-of-interest CVR values. The maps are given in their original space as well as standardized MNI space. The pipeline has been shown to procure results corresponding to accepted CVR processing techniques that rely on manual intervention. This pipeline has potential to streamline other researchers’ acquisition of CVR values in subjects.