Abstract #0244

The developing Human Connectome Project (dHCP): fetal acquisition protocol

Anthony N Price^1,2, Lucilio Cordero-Grande^1,2, Emer Hughes¹, Suzanne Hiscocks¹, Elaine Green¹, Laura McCabe¹, Jana Hutter¹, Giulio Ferrazzi¹, Maria Deprez², Thomas Roberts², Daan Christiaens², Eugene Duff³, Vyacheslav Karolis³, Shaihan J Malik², Mary A Rutherford¹, David A Edwards¹, and Joseph V Hajnal^1,2

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Biomedical Engineering Department, King's College London, London, United Kingdom, ³FMRIB, Oxford University, Oxford, United Kingdom

The developing Human Connectome Project seeks to map connectivity in the human brain based on structural, functional and diffusion MRI data acquired from over 1000 subjects (neonatal and fetal). A dedicated acquisition protocol has been developed to efficiently image fetal brain in utero. We describe here the methods and parameters being used alongside initial pre-processing steps. The acquisition protocol has been tuned to complement the neonatal data already collected while adapting to the difficult challenges of imaging the fetal brain in utero. It has been deployed to image over 145 fetuses to date with a success rate of ~90%.

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