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Abstract #0245

Inversion Recovery Zero Echo Time (IR-ZTE) Imaging for Direct Myelin Detection in Human Brain

Hyungseok Jang1, Michael Carl2, Yajun Ma1, Yanjun Chen1, Saeed Jerban1, Eric Y Chang1,3, and Jiang Du1

1Department of Radiology, University of California San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

In MRI, direct myelin imaging is challenging due to the short T2* decay (less than 0.5ms) and very low proton density. In the literature, it has been reported that ultrashort echo time (UTE) imaging can directly capture the fast decaying myelin signal. To further enhance the dynamic range, adiabatic inversion recovery (IR) preparation can be utilized so that the white matter signal can be suppressed. Moreover, dual echo UTE imaging scheme can suppress the remaining gray matter signal. In this study, we explore the feasibility of IR prepared zero echo time (IR-ZTE) imaging for direct myelin imaging in the human brain.

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