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Abstract #0251

Quantitative Susceptibility Mapping: In Vivo Biomarkers for Cerebral Cavernous Malformations Related Epilepsy

Li Ma1,2,3, Chunxue Wu4, Shuo Zhang1,2, Zongze Li3, Lizhi Xie5, Xiaolin Chen1,2,3, Xun Ye1,2, Hao Wang1,2, Yuanli Zhao1,2,3, Shuo Wang1,2, and Jizong Zhao1,2

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 2China National Clinical Research Center for Neurological Diseases, Beijing, China, 3Department of Neurosurgery, Peking University International Hospital, Beijing, China, 4Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 5GE Healthcare, China, Beijing, China

Hemosiderin deposits surrounding the cerebral cavernous malformations (CCMs) had been proposed to be associated with the pathogenesis of CCM-related epilepsy (CRE). An increased perilesional and extralesional iron deposition were found in CCMs with epilepsy through susceptibility maps of quantitative susceptibility mapping (QSM). To investigate novel biomarkers for the in vivo and longitudinal evaluation of CCM lesions with epilepsy, this study was to explore the iron quantity in CCMs patients with CRE using quantitative susceptibility mapping.

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