Abstract #0251

Quantitative Susceptibility Mapping: In Vivo Biomarkers for Cerebral Cavernous Malformations Related Epilepsy

Li Ma^1,2,3, Chunxue Wu⁴, Shuo Zhang^1,2, Zongze Li³, Lizhi Xie⁵, Xiaolin Chen^1,2,3, Xun Ye^1,2, Hao Wang^1,2, Yuanli Zhao^1,2,3, Shuo Wang^1,2, and Jizong Zhao^1,2

¹Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ²China National Clinical Research Center for Neurological Diseases, Beijing, China, ³Department of Neurosurgery, Peking University International Hospital, Beijing, China, ⁴Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁵GE Healthcare, China, Beijing, China

Hemosiderin deposits surrounding the cerebral cavernous malformations (CCMs) had been proposed to be associated with the pathogenesis of CCM-related epilepsy (CRE). An increased perilesional and extralesional iron deposition were found in CCMs with epilepsy through susceptibility maps of quantitative susceptibility mapping (QSM). To investigate novel biomarkers for the in vivo and longitudinal evaluation of CCM lesions with epilepsy, this study was to explore the iron quantity in CCMs patients with CRE using quantitative susceptibility mapping.

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