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Abstract #0259

Kinetic Modeling of Hyperpolarized [1-13C]Lactate Metabolism in a Mouse Model of Ischemic Stroke

Thanh Phong Lê1,2, Lara Buscemi3, Elise Vinckenbosch1, Mario Lepore4, Rolf Gruetter 2,5,6, Lorenz Hirt 3, Jean-Noël Hyacinthe 1,7, and Mor Mishkovsky 2

1Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland, 2Laboratory of Functional and Metabolic Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Department of Clinical Neurosciences, Centre hospitalier universitaire Vaudois (CHUV), Lausanne, Switzerland, 4Centre d'Imagerie Biomédicale (CIBM), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, 6Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland, 7Image Guided Intervention Laboratory, University of Geneva (UNIGE), Geneva, Switzerland

Stroke is the second cause of death and third leading cause of disability worldwide. Lactate injection was found to provide neuroprotection in preclinical models of ischemic stroke.

Alteration of the metabolism induced by ischemia can be measured in real time using magnetic resonance with hyperpolarized 13C labeled probes.

This study aims at investigating the feasibility of quantifying changes in the kinetics of hyperpolarized [1-13C]lactate metabolism following ischemia in a mouse model of stroke in order to assess the potential of hyperpolarized lactate as a theranostic agent for stroke.

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