Abstract #0259

Kinetic Modeling of Hyperpolarized [1-13C]Lactate Metabolism in a Mouse Model of Ischemic Stroke

Thanh Phong Lê^1,2, Lara Buscemi³, Elise Vinckenbosch¹, Mario Lepore⁴, Rolf Gruetter ^2,5,6, Lorenz Hirt ³, Jean-Noël Hyacinthe ^1,7, and Mor Mishkovsky ²

¹Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland, ²Laboratory of Functional and Metabolic Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Department of Clinical Neurosciences, Centre hospitalier universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁴Centre d'Imagerie Biomédicale (CIBM), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, ⁶Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland, ⁷Image Guided Intervention Laboratory, University of Geneva (UNIGE), Geneva, Switzerland

Stroke is the second cause of death and third leading cause of disability worldwide. Lactate injection was found to provide neuroprotection in preclinical models of ischemic stroke.

Alteration of the metabolism induced by ischemia can be measured in real time using magnetic resonance with hyperpolarized ¹³C labeled probes.

This study aims at investigating the feasibility of quantifying changes in the kinetics of hyperpolarized [1-¹³C]lactate metabolism following ischemia in a mouse model of stroke in order to assess the potential of hyperpolarized lactate as a theranostic agent for stroke.

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