Abstract #0259

Kinetic Modeling of Hyperpolarized [1-13C]Lactate Metabolism in a Mouse Model of Ischemic Stroke

Thanh Phong Lê^1,2, Lara Buscemi³, Elise Vinckenbosch¹, Mario Lepore⁴, Rolf Gruetter ^2,5,6, Lorenz Hirt ³, Jean-Noël Hyacinthe ^1,7, and Mor Mishkovsky ²

¹Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland, ²Laboratory of Functional and Metabolic Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Department of Clinical Neurosciences, Centre hospitalier universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁴Centre d'Imagerie Biomédicale (CIBM), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, ⁶Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland, ⁷Image Guided Intervention Laboratory, University of Geneva (UNIGE), Geneva, Switzerland

Stroke is the second cause of death and third leading cause of disability worldwide. Lactate injection was found to provide neuroprotection in preclinical models of ischemic stroke.

Alteration of the metabolism induced by ischemia can be measured in real time using magnetic resonance with hyperpolarized ¹³C labeled probes.

This study aims at investigating the feasibility of quantifying changes in the kinetics of hyperpolarized [1-¹³C]lactate metabolism following ischemia in a mouse model of stroke in order to assess the potential of hyperpolarized lactate as a theranostic agent for stroke.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.