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Abstract #0261

Fluorine-19 MR at 21.1 Tesla for Enhanced Detection of Brain Inflammation

Sonia Waiczies1, Jens Rosenberg2, Paula Ramos Delgado1, Ludger Starke1, Joao dos Santos Periquito 1, Christian Prinz1, Jason M. Millward1, Andre Kuehne3, Helmar Waiczies3, Andreas Pohlmann1, and Thoralf Niendorf1

1Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 3MRI TOOLs GmbH, Berlin, Germany

Fluorine-19 (19F) MR methods are invaluable for several applications including detection of brain inflammation but suffer from inherently low signal-to noise ratio (SNR). A magnetic field increase from 9.4 to 21.1 Tesla was studied as strategy for increasing signal sensitivity. As a result of an SNR increase, inflammation regions undetected at 9.4T were revealed at 21.1T. Although the SNR gain at 21.1T does not reach that achieved with a cryogenic quadrature RF surface probe (19F-CRP) at 9.4T, increased sensitivity was observed throughout the whole field of view at 21.1T, from ventral to dorsal head regions.

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