Abstract #0261

Fluorine-19 MR at 21.1 Tesla for Enhanced Detection of Brain Inflammation

Sonia Waiczies¹, Jens Rosenberg², Paula Ramos Delgado¹, Ludger Starke¹, Joao dos Santos Periquito ¹, Christian Prinz¹, Jason M. Millward¹, Andre Kuehne³, Helmar Waiczies³, Andreas Pohlmann¹, and Thoralf Niendorf¹

¹Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, ³MRI TOOLs GmbH, Berlin, Germany

Fluorine-19 (¹⁹F) MR methods are invaluable for several applications including detection of brain inflammation but suffer from inherently low signal-to noise ratio (SNR). A magnetic field increase from 9.4 to 21.1 Tesla was studied as strategy for increasing signal sensitivity. As a result of an SNR increase, inflammation regions undetected at 9.4T were revealed at 21.1T. Although the SNR gain at 21.1T does not reach that achieved with a cryogenic quadrature RF surface probe (¹⁹F-CRP) at 9.4T, increased sensitivity was observed throughout the whole field of view at 21.1T, from ventral to dorsal head regions.

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