Abstract #0287

Arterial Spin Labeling Underestimates CBF in Regions with Fast Arrival Times: a Simultaneous [15O] PET/MRI Study with Acetazolamide Challenge

Yosuke Ishii^1,2, Thoralf Thamn^1,3, Jia Guo^1,4, Mohammad Mehdi Khalighi⁵, Mirwais Wardak¹, Dawn Holley¹, Harsh Gandhi¹, Jun Hyung Park¹, Bin Shen¹, Gary K Steinberg⁶, Frederick T Chin¹, Greg Zaharchuk¹, and Audrey Peiwen Fan¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Neurosurgery, Tokyo Medial and Dental University, Tokyo, Japan, ³Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Bioengineering, University of California Riverside, Riverside, CA, United States, ⁵Global Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, ⁶Neurosurgery, Stanford University, Stanford, CA, United States

In this study, we investigated the effects of arterial transit time (ATT) reduction and the quantitative accuracy of standard and multi-delay arterial spin labeling (ASL) MRI on healthy controls and Moyamoya patients using acetazolamide (ACZ) by the voxel-wise parametric testing.

Administration of ACZ shortened ATT and extended the region where cerebral blood flow (CBF) was underestimated by standard ASL and by multi-delay ASL compared to simultaneous [¹⁵O]-water PET reference. Consideration of short ATT is critical for accurate ASL measurements of CBF in the deep gray matter and for quantification of cerebrovascular reactivity after a vasodilation challenge that decreases ATT.

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