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Abstract #0287

Arterial Spin Labeling Underestimates CBF in Regions with Fast Arrival Times: a Simultaneous [15O] PET/MRI Study with Acetazolamide Challenge

Yosuke Ishii1,2, Thoralf Thamn1,3, Jia Guo1,4, Mohammad Mehdi Khalighi5, Mirwais Wardak1, Dawn Holley1, Harsh Gandhi1, Jun Hyung Park1, Bin Shen1, Gary K Steinberg6, Frederick T Chin1, Greg Zaharchuk1, and Audrey Peiwen Fan1

1Radiology, Stanford University, Stanford, CA, United States, 2Neurosurgery, Tokyo Medial and Dental University, Tokyo, Japan, 3Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Bioengineering, University of California Riverside, Riverside, CA, United States, 5Global Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, 6Neurosurgery, Stanford University, Stanford, CA, United States

In this study, we investigated the effects of arterial transit time (ATT) reduction and the quantitative accuracy of standard and multi-delay arterial spin labeling (ASL) MRI on healthy controls and Moyamoya patients using acetazolamide (ACZ) by the voxel-wise parametric testing.

Administration of ACZ shortened ATT and extended the region where cerebral blood flow (CBF) was underestimated by standard ASL and by multi-delay ASL compared to simultaneous [15O]-water PET reference. Consideration of short ATT is critical for accurate ASL measurements of CBF in the deep gray matter and for quantification of cerebrovascular reactivity after a vasodilation challenge that decreases ATT.

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