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Abstract #0288

ASL signal model for simultaneously measuring CBF and CBV based on ASL imaging for characterizing hemodynamic perfusion state in normal subjects and patients with moyamoya disease.

Hirohiko Kimura1, Yoshifumi Higashino2, Shota Ishida3,4, Naoyuki Takei5, Yasuhiro Fujiwara6, Masayuki Kanamoto3, Nobuyuki Kosaka7, and Hiroyuki Kabasawa8

1Radiology, University of Fukui, Fukui, Japan, 2Neurosurgery, University of Fukui, Fukui, Japan, 3Radiological center, University of Fukui Hospital, Fukui, Japan, 4Division of Health Sciences, Graduate school of Medical Sciences, Kanazawa University, Kanazawa, Japan, 5MR application and Workflow, GE Healthcare JAPAN, HIno, Japan, 6Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 7Department of Radiology, University of Fukui, Fukui, Japan, 8GE Healthcare JAPAN, Hino, Japan

Not only cerebral blood flow (CBF) but also cerebral blood volume (CBV) plays an important role for the maintenance of cerebral blood perfusion. We hypothesized that the ASL signal difference caused by vessel suppression (VS) scheme should be dependent on arterial CBV fraction of total ASL signal. In this study, we introduced modified two-compartments model based on ASL signal with and without VS, so that we can calculate arterial volume fraction of total ASL signal. The objective of this study is to demonstrate the feasibility of arterial CBV map as well as CBF based on ASL imaging.

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