Abstract #0288

ASL signal model for simultaneously measuring CBF and CBV based on ASL imaging for characterizing hemodynamic perfusion state in normal subjects and patients with moyamoya disease.

Hirohiko Kimura¹, Yoshifumi Higashino², Shota Ishida^3,4, Naoyuki Takei⁵, Yasuhiro Fujiwara⁶, Masayuki Kanamoto³, Nobuyuki Kosaka⁷, and Hiroyuki Kabasawa⁸

¹Radiology, University of Fukui, Fukui, Japan, ²Neurosurgery, University of Fukui, Fukui, Japan, ³Radiological center, University of Fukui Hospital, Fukui, Japan, ⁴Division of Health Sciences, Graduate school of Medical Sciences, Kanazawa University, Kanazawa, Japan, ⁵MR application and Workflow, GE Healthcare JAPAN, HIno, Japan, ⁶Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ⁷Department of Radiology, University of Fukui, Fukui, Japan, ⁸GE Healthcare JAPAN, Hino, Japan

Not only cerebral blood flow (CBF) but also cerebral blood volume (CBV) plays an important role for the maintenance of cerebral blood perfusion. We hypothesized that the ASL signal difference caused by vessel suppression (VS) scheme should be dependent on arterial CBV fraction of total ASL signal. In this study, we introduced modified two-compartments model based on ASL signal with and without VS, so that we can calculate arterial volume fraction of total ASL signal. The objective of this study is to demonstrate the feasibility of arterial CBV map as well as CBF based on ASL imaging.

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