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Abstract #0295

Differences in temporal cerebrovascular reactivity responses between patients with atherosclerotic and non-atherosclerotic intracranial disease: implications for optimal hypercapnic reactivity experiments

Meher Juttukonda1, Larry Davis1, Spencer Waddle1, Sarah Lants1, Matthew Fusco2, and Manus Donahue1

1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States

Intracranial stenosis may be due to atherosclerotic or idiopathic non-atherosclerotic mechanisms, and each condition may incur different consequences on cerebral hemodynamics. The purpose of this study was to use a time regression analysis approach applied to hypercapnic BOLD fMRI data to evaluate how cerebrovascular reactivity (CVR) timing and maximum CVR may differ between patient groups and with vasculopathy extent. Time-to-maximum CVR may be lengthened in territories supplied by stenotic vessels in both patient groups; however, maximum CVR may be reduced on average only in patients with non-atherosclerotic disease, potentially indicating that arteriolar smooth muscle and/or endothelial function may differ substantially between conditions.

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