Abstract #0296

In-vivo validation of T2- and susceptibility-based SvO2 measurements with jugular vein catheterization under hypoxia and hypercapnia

Xin Miao¹, Krishna Nayak^1,2, and John Wood^1,3

¹Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ³Division of Cardiology, Children’s Hospital Los Angeles, Los angeles, CA, United States

This study aimed to validate T2- and susceptibility-based cerebral venous oxygen saturation (S_vO₂) measurements with the clinical standard, jugular vein catheterization. T2-relaxation-under-tagging (TRUST) and susceptibility-based oximetry (SBO) were performed on two healthy subjects with jugular catheterization and eleven subjects without catheterization under baseline, hypoxia and hypercapnia. TRUST tightly agreed with the jugular reference under hypercapnia but significantly underestimated S_vO₂ under baseline and hypoxia. Bias between SBO and the reference was independent on the physiological state. A proportional bias was observed comparing TRUST and SBO. The results suggested caution for inter-subject comparison of absolute S_vO₂ measurements using either TRUST or SBO.

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