Abstract #0297

Investigating tissue microstructure using NODDI and histology: A chronic injury study on ex vivo macaque spinal cords

Andrew Bauman^1,2, Andrew Yung^1,2, Jie Liu³, Junhao Liu⁴, Qingan Zhu⁴, Piotr Kozlowski^1,2,3, and Wolfram Tetzlaff³

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²UBC MRI Research Centre, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ⁴Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

In this study we sought to understand whether Neurite Orientation Dispersion and Density Imaging (NODDI) could accurately delineate the extent of microstructure damage in an ex-vivo macaque spinal cord. We used histology as a gold standard for delineating the margin between damaged and undamaged tissue. Qualitative analysis exposed disagreements between NODDI maps and histology in areas of damage. This suggests that NODDI may not be appropriate for this model of chronic spinal cord injury.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.