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Abstract #0297

Investigating tissue microstructure using NODDI and histology: A chronic injury study on ex vivo macaque spinal cords

Andrew Bauman1,2, Andrew Yung1,2, Jie Liu3, Junhao Liu4, Qingan Zhu4, Piotr Kozlowski1,2,3, and Wolfram Tetzlaff3

1Radiology, University of British Columbia, Vancouver, BC, Canada, 2UBC MRI Research Centre, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

In this study we sought to understand whether Neurite Orientation Dispersion and Density Imaging (NODDI) could accurately delineate the extent of microstructure damage in an ex-vivo macaque spinal cord. We used histology as a gold standard for delineating the margin between damaged and undamaged tissue. Qualitative analysis exposed disagreements between NODDI maps and histology in areas of damage. This suggests that NODDI may not be appropriate for this model of chronic spinal cord injury.

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