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Abstract #0299

Advanced Magnetic Resonance techniques in Post-Mortem Human Spinal Cord Injury: Correlations with Histopathology

Sarah R. Morris1,2,3, Valentin Prevost1,2, Piotr Kozlowski1,2,3,4, Andrew Yung1,2,4, Andrew Bauman1,2,4, Zahra Samadi B.1,5, Caron Samadi Fournier1,5, Allan Aludino1,6, Lisa Parker7, Kevin Dong1, Femke Streijger1, G. R. Wayne Moore1,5,8, Brian Kwon1,6, and Cornelia Laule1,2,3,5

1International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 4UBC MRI Research Centre, Vancouver, BC, Canada, 5Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6Vancouver Spine Surgery Institute, Vancouver, BC, Canada, 7Vancouver General Hospital, Vancouver, BC, Canada, 8Medicine, University of British Columbia, Vancouver, BC, Canada

Spinal cord injury prognosis assessments rely on subjective clinical evaluations and often poorly predict outcome; quantitative imaging biomarkers for spinal cord injury evaluation would aid clinical decision making. Our study applied two advanced MRI techniques to the imaging of post-mortem human spinal cord injury samples. We compared in-homogeneous magnetisation transfer and NODDI metric maps with six histological stains to relate the MR image contrast to biological correlates. We found a correlation trend between ihMT signal with strong T1D-filtering and Luxol Fast Blue optical density (myelin phospholipid stain) in white and grey matter.

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