Abstract #0299

Advanced Magnetic Resonance techniques in Post-Mortem Human Spinal Cord Injury: Correlations with Histopathology

Sarah R. Morris^1,2,3, Valentin Prevost^1,2, Piotr Kozlowski^1,2,3,4, Andrew Yung^1,2,4, Andrew Bauman^1,2,4, Zahra Samadi B.^1,5, Caron Samadi Fournier^1,5, Allan Aludino^1,6, Lisa Parker⁷, Kevin Dong¹, Femke Streijger¹, G. R. Wayne Moore^1,5,8, Brian Kwon^1,6, and Cornelia Laule^1,2,3,5

¹International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁴UBC MRI Research Centre, Vancouver, BC, Canada, ⁵Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Vancouver Spine Surgery Institute, Vancouver, BC, Canada, ⁷Vancouver General Hospital, Vancouver, BC, Canada, ⁸Medicine, University of British Columbia, Vancouver, BC, Canada

Spinal cord injury prognosis assessments rely on subjective clinical evaluations and often poorly predict outcome; quantitative imaging biomarkers for spinal cord injury evaluation would aid clinical decision making. Our study applied two advanced MRI techniques to the imaging of post-mortem human spinal cord injury samples. We compared in-homogeneous magnetisation transfer and NODDI metric maps with six histological stains to relate the MR image contrast to biological correlates. We found a correlation trend between ihMT signal with strong T_1D-filtering and Luxol Fast Blue optical density (myelin phospholipid stain) in white and grey matter.

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