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Abstract #0300

Cervical Spine inhomogeneous Magnetization Transfer (ihMT) Imaging Using ECG-Triggered 3D Rapid Acquisition Gradient-Echo (ihMT-RAGE)

Thomas Troalen1, Virginie Callot2,3, Gopal Varma4, Arash Forodighasemabadi2,3, Maxime Guye2,3, David C Alsop4, Guillaume Duhamel2,3, and Olivier M Girard2,3

1Siemens Healthcare SAS, Saint-Denis, France, 2Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 3APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 4Radiology, Division of MR research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) is a promising MRI modality that provides high sensitivity and specificity to myelinated tissue. Demyelinating pathologies in the central nervous system could then be addressed by this technique. The goal of this work is to demonstrate that the combination of ihMT preparation with Rapid Acquisition Gradient Echo (ihMT-RAGE), as recently proposed for the brain, can be adapted to an ECG-triggered 3D exploration of the cervical spinal cord within a clinically-compatible scan time. The in-vivo ihMT results from healthy cervical spinal cord demonstrate the great potential of the ihMT-RAGE technique for future investigations of degenerative spinal cord pathologies.

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