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Abstract #0301

Intra-Voxel Incoherent Motion at 7T to quantify human spinal cord microperfusion: pitfalls and promises

Simon Levy1,2,3,4, Stanislas Rapacchi1,2, Aurélien Massire1,2,4, Thorsten Feiweier5, Maxime Guye1,2, Thomas Troalen6, and Virginie Callot1,2,4

1Faculty of Medicine, Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hopital Universitaire Timone, CEMEREM, Marseille, France, 3Faculty of Medicine, Aix-Marseille Univ, IFSTTAR, LBA, Marseille, France, 4iLab-Spine International Associated Laboratory, France-Canada, Marseille-Montreal, France, 5Siemens Healthcare GmbH, Erlangen, Germany, 6Siemens Healthcare SAS, Saint-Denis, France

Spinal cord microperfusion assessment in human is challenging but would greatly help characterize tissue integrity and surgery decision-making. Intra-Voxel Incoherent Motion (IVIM) microperfusion measurement is promising but remains highly Signal-to-Noise ratio (SNR) demanding. Monte-Carlo simulations show that IVIM two-step segmented fitting approach is less accurate than directly fitting the bi-exponential representation to all b-values. Simulations also help quantify required SNR and estimation errors to measure IVIM parameters in the context of low perfusion. Exploiting 7T SNR gain, large number of repetitions and group average, IVIM was able to unveil the gray matter higher microperfusion-related pattern, compared to white matter, in agreement with brain studies.

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