Abstract #0302

Cervical spinal cord diffusion MRI and intraspinal space restriction at the occipito-cervical junction in mucopolysacharidoses patients

Igor Nestrasil^1,2, Rene Labounek^1,3, Carol Nguyen¹, Ivan Krasovec¹, Jan Valosek^3,4, Alena Svatkova^1,5, Julien Cohen-Adad⁶, Christophe Lenglet², and Chester Whitley¹

¹Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ³Department of Neurology, Palacky University, Olomouc, Czech Republic, ⁴Department of Biomedical Engineering, University Hospital Olomouc, Olomouc, Czech Republic, ⁵Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, ⁶Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada

The overall goal of this project is to establish novel MRI parameters for reliable detection of cervical spinal cord (CSC) microstructural abnormalities in patients with Mucopolysaccharidosis (MPS) that develop prior to the clinical manifestation of spinal cord damage. Quantitative analysis of diffusion MRI (dMRI) may characterize microstructural alterations of CSC with high sensitivity. In this study measures of CSC microstructure were determined by dMRI using a protocol based on the RESOLVE (REadout Segmentation Of Long Variable Echo trains) sequence. Derived diffusion metrics were then related to the anatomical measures of the cervical spine in patients with MPS.

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