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Abstract #0308

Three-Dimensional Whole Brain Simultaneous T1, T2, and Apparent Diffusion Coefficient Mapping Using MR Multitasking

Sen Ma1,2, Anthony G Christodoulou2, Christopher T Nguyen2,3, Fei Han4, Nan Wang1,2, Yibin Xie2, and Debiao Li1,2

1Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 4Siemens Healthcare, Los Angeles, CA, United States

Three-dimensional, multi-parametric quantitative mapping of relaxation and diffusion parameters is desirable for many clinical imaging application, including the diagnosis and follow-up assessment of tumors. Traditionally, this is performed by separate scans which are time-consuming. We propose a novel Multitasking framework to achieve 3D whole-brain simultaneous T1/T2/ADC mapping in ~9min. The underlying multidimensional image is modeled as a low-rank tensor, with a time-resolved phase correction technique to compensate for the phase inconsistency induced by pulsatile motion during diffusion preparation. T1/T2/ADC measurements in healthy volunteers agree with reference methods, yielding intraclass correlation coefficients > 0.80 for both gray and white matter.

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