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Abstract #0309

Magnetization transfer (MT) of human brain at 7T in the context of a 3D multi-parameter mapping protocol

Hampus Olsson1, Mads Andersen2,3, Jimmy Lätt4,5, Ronnie Wirestam1, and Gunther Helms1,3

1Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, 2Philips Danmark A/S, Philips Healthcare, Copenhagen, Denmark, 3National 7T Facility, Lund University, Lund, Sweden, 4Centre for Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden, 5Clinical Sciences Lund, Department of Radiology, Lund University, Lund, Sweden

3D multi-gradient echo MRI can be used to estimate T1, T2*, PD and the magnetization transfer (MT), which is increasingly used for multi-parametric mapping (MPM) of human brain. The increased polarization at 7T compared to lower B0 allows for increased spatial resolution or reduced scan times. However, SAR restrictions imposed on the MT pulse and B1 inhomogeneity pose challenges. In this work, we propose a protocol for MPM of human brain at 7T with special attention paid to eliminating bias when mapping MTsat while obtaining submillimeter isotropic spatial resolution in under 12 minutes with acceptable SNR.

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