Echo planar time-resolved imaging (EPTI) is a multi-contrast quantitative imaging technique, which achieved fast acquisition of distortion- and blurring-free images at multiple echo times (TE). To improve the SNR and accuracy of EPTI at high-accelerations, in this study, we developed a subspace-constrained reconstruction for EPTI and proposed new k-t sampling trajectories to take advantage of this reconstruction. The subspace reconstruction is also augmented with phase-cycling to extract high-resolution phase data, without need of high-resolution B0 calibration scan. Using the proposed approach, whole-brain 1.1mm-isotropic multi-echo images, and T2* and B0 maps are reconstructed from 3D-EPTI data acquired within 50 seconds.
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