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Abstract #0327

Targeting brain and cognitive aging with multi-modal imaging and connectome topography profiling

Alexander J. Lowe1, Casey Paquola1, Reinder Vos de Wael1, Sara Lariviere1, Shahin Tavakol1, Benoit Caldairou2, Neda Bernasconi2, Andrea Bernasconi2, Nathan Spreng3, and Boris C. Bernhardt1

1Multimodal Imaging and Connectome Laboratory, Montreal Neurological Institute, Montreal, QC, Canada, 2Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, Montreal, QC, Canada, 3Brain and Cognition Laboratory, Montreal Neurological Institute, Montreal, QC, Canada

We present an approach to represent and analyze age-related differences in cortical morphology and Aβ uptake based on connectome topography. Studying healthy individuals, we observed age-related reductions in neocortical thickness and atrophy across posterior hippocampal subfields. Additionally, we observed an interplay between aging effects and functional topography in both neocortical and hippocampal regions, with age-related thinning stronger towards unimodal regions and Aβ deposition increasing towards transmodal regions. Similarly, an inverted pattern of volume loss and Aβ deposition was observed along the hippocampal long-axis. Finally, imaging markers were found to predict cognitive performance in a topography-specific manner.

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