We investigated the relationship between structural brain health with age and cardiovascular risks across the adult life course. A score of the Brain Atrophy and Lesion Index (BALI), which assesses and integrates multiple changes commonly seen on MRI in the aging brain, was generated for each subject from evaluation of T2-weighted MRI. Our data showed that the accumulation of MRI detectable deficits in the brain became evident even in younger adults. Cardiovascular risks strongly affected the whole-brain structural health, in addition to the effect of age.
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