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Abstract #0336

Hippocampal NAA/mIns ratio and spatial working memory across the lifespan

Anna Lind1, Carl-Johan Boraxbekk1, Hartwig Roman Siebner1,2,3, Esben Thade Petersen1,4, and Anouk Marsman1

1Danish Research Center for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 3Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 4Center for Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark

The NAA/mIns ratio has been proposed as a marker of unhealthy ageing. We found that the NAA/mIns ratio is decreased in the hippocampus for middle-aged and old individuals compared to young individuals. For old individuals, declining NAA/mIns ratios are correlated with poorer performance on a spatial working memory task but this relationship is not found in middle-aged and young individuals. Our results suggest that the NAA/mIns ratio decrease in the hippocampus is observable before the negative functional effects.

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