Perivascular spaces (PVS) are an integral part of the brain’s glymphatic system. Although enlarged PVSs are often observed in older population and patient with neurological diseases, normal PVS morphological features in healthy subjects and their age dependences remain poorly understood. We studied the age-dependence of PVS morphology in healthy volunteers aged 21 – 55. The number and diameters of PVSs were positively correlated with age but exhibited large inter-subject variations. We also found clear spatial heterogeneity in the density of visible PVSs. Further studies are needed to realize the utility of PVS as a potential biomarker for aging and neurological diseases.
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