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Abstract #0345

Distortion-free diffusion-weighted imaging of the eyeballs and the optic nerves using PSF-EPI

Jieying Zhang1, Yishi Wang1,2, Yuhui Xiong1, and Hua Guo1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Philips Healthcare, Beijing, China

Distortion-free diffusion-weighted imaging can provide high fidelity information for the diagnosis of ophthalmological diseases. Traditional echo-planar imaging technique suffers from geometric distortion in the skull base. This study applies a point spread function encoded technique in eyeball imaging. This technique can generate distortion-free DWI of the eyeballs and the optic nerves with high efficiency. Its resistance to geometric distortion and ability to generate accurate ADCs were validated on phantom and healthy subjects. This technique has the potential in providing accurate information for diagnosis and characterizing diseases that are difficult to distinguish by traditional imaging methods.

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