Distortion-free diffusion-weighted imaging can provide high fidelity information for the diagnosis of ophthalmological diseases. Traditional echo-planar imaging technique suffers from geometric distortion in the skull base. This study applies a point spread function encoded technique in eyeball imaging. This technique can generate distortion-free DWI of the eyeballs and the optic nerves with high efficiency. Its resistance to geometric distortion and ability to generate accurate ADCs were validated on phantom and healthy subjects. This technique has the potential in providing accurate information for diagnosis and characterizing diseases that are difficult to distinguish by traditional imaging methods.
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