16p22.1 deletion syndrome has been implicated in disorders such as autism and is associated with developmental deficits, including delay in language acquisition. Widespread DTI white-matter alterations have been identified in patients but the structural organisation using network theory has yet to be investigated. Using rich-club nodes to stratify the connectome into rich-club, feeder and seeder subnetworks, we compute graph topological measures in children with 16p11.2 deletion. While rich-club regions were similar to those in Controls, differential alterations in connectivity and topology suggest a reorganisation of subnetworks in patients with the feeder subnetwork possibly compensating for deficits in the rich-club.
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