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Abstract #0346

Defining subnetworks by rich-club architecture in 16p11.2 deletion syndrome reveals differential structural white-matter alterations

Ai Wern Chung1, Banu Ahtam1, P. Ellen Grant1, and Kiho Im1

1Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States

16p22.1 deletion syndrome has been implicated in disorders such as autism and is associated with developmental deficits, including delay in language acquisition. Widespread DTI white-matter alterations have been identified in patients but the structural organisation using network theory has yet to be investigated. Using rich-club nodes to stratify the connectome into rich-club, feeder and seeder subnetworks, we compute graph topological measures in children with 16p11.2 deletion. While rich-club regions were similar to those in Controls, differential alterations in connectivity and topology suggest a reorganisation of subnetworks in patients with the feeder subnetwork possibly compensating for deficits in the rich-club.

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