Abstract #0347

Topological reorganizations of the white matter structural networks in early blind adolescents

Zhifeng Zhou¹, Leilei Shi², Xia Liu¹, Long Qian³, and Hengguo Li⁴

¹Department of Radiology, Shenzhen Mental Health Center, Shenzhen Kangning Hospital, Shenzhen, China, ²Department of Mechanical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ³GE Healthcare, MR Research China, Beijing, China, ⁴Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China

Previous neuroimaging studies have revealed functional neuroplasticity after visual deprivation. However, the structural reorganization of the brain induced by visual deprivation is rarely reported, and the mechanism of structural neuroplasticity remains unclear. This study is one of the first attempts to investigate structural neuroplasticity in the white matter networks at both the global and the local node levels using the Diffusion Tensor Imaging data and the graph theory analysis method. The results demostrate disrupted brain structure and reorganized brain structural networks in early blind adolecents, which provide evidence of structural neuroplasticity induced by visual deprevation.

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