Abstract #0360

Attention modulation of layer-specific signals in human visual cortex

Chengwen Liu^1,2, Chencan Qian¹, Zihao Zhang^1,3, Kaibao Sun¹, Jing An⁴, Danny J.J. Wang^5,6, and Peng Zhang^1,2

¹State Key Lab of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, ⁴Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, ⁵Department of Neurology, University of California Los Angeles, Los Angeles, CA, United States, ⁶Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States

Attention mechanisms at different cortical layers of the human visual cortex remain poorly understood. Here we investigated the attention modulation of layer-specific activities in the human visual cortex, using submillimeter-resolution BOLD fMRI at 7 Tesla. Results showed that compared to the middle-layer activities, attention increased signals in the superficial and deep layers of V1, and in the superficial layers of V2 and V3. Contrast modulation was strongest in the middle layer of V1, consistent with the feedforward input from the LGN. These findings suggest that top-down spatial attention mainly modulates output signals in the superficial layers of human visual cortex.

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