Abstract #0361

Assessing somatotopic and mototopic organisation in Focal Hand Dystonia using high-resolution 7T fMRI

Daisie Pakenham¹, Michael Asghar¹, Paul Glover¹, George O'Neill¹, Ayan Sengupta¹, Denis Schluppeck², Rosa Sanchez-Panchuelo¹, Miles Humberstone³, and Susan Francis¹

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²School of Psychology, University of Nottingham, Nottingham, United Kingdom, ³Department of Neurology, Nottingham University Hospitals Trust, University of Nottingham, Nottingham, United Kingdom

7T fMRI provides a non-invasive method to study somatotopy and mototopy. Here, healthy controls (HCs) and Focal Hand Dystonia (FHD) patients 4-weeks post-Botox injection undergo behavioural and fMRI assessment. Behavioural measures include temporal discrimination, amplitude thresholding and spatial acuity assessment. fMRI includes a somatosensory travelling wave and event-related paradigm, and mototopy travelling wave paradigm. In FHD patients, amplitude threshold, temporal discrimination threshold and spatial acuity was increased compared to HCs. Maps of somatotopy and mototopy are shown for FHD patients and HCs along with digit separation. FHD patients will be rescanned 3 months post-Botox to determine whether changes are evident.

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