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Abstract #0361

Assessing somatotopic and mototopic organisation in Focal Hand Dystonia using high-resolution 7T fMRI

Daisie Pakenham1, Michael Asghar1, Paul Glover1, George O'Neill1, Ayan Sengupta1, Denis Schluppeck2, Rosa Sanchez-Panchuelo1, Miles Humberstone3, and Susan Francis1

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2School of Psychology, University of Nottingham, Nottingham, United Kingdom, 3Department of Neurology, Nottingham University Hospitals Trust, University of Nottingham, Nottingham, United Kingdom

7T fMRI provides a non-invasive method to study somatotopy and mototopy. Here, healthy controls (HCs) and Focal Hand Dystonia (FHD) patients 4-weeks post-Botox injection undergo behavioural and fMRI assessment. Behavioural measures include temporal discrimination, amplitude thresholding and spatial acuity assessment. fMRI includes a somatosensory travelling wave and event-related paradigm, and mototopy travelling wave paradigm. In FHD patients, amplitude threshold, temporal discrimination threshold and spatial acuity was increased compared to HCs. Maps of somatotopy and mototopy are shown for FHD patients and HCs along with digit separation. FHD patients will be rescanned 3 months post-Botox to determine whether changes are evident.

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