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Abstract #0373

Measuring large lipid droplet sizes by probing restricted lipid diffusion effects with Diffusion-Weighted Magnetic Resonance Spectroscopy at 3 T

Dominik Weidlich1, Julius Honecker2, Oliver Gmach3, MingMing Wu1, Rainer Burgkart4, Stefan Ruschke1, Daniela Franz1, Bjoern H. Menze5, Thomas Skurk2, Hans Hauner2, Ulrich Kulozik3, and Dimitrios C. Karampinos1

1Department of Diagnostic and Interventional Radiology, Technical University Munich, Munich, Germany, 2Else Kröner Fresenius Center for Nutritional Medicine, Technical University Munich, Munich, Germany, 3Chair for Food and Bioprocess Engineering, Technical University Munich, Freising, Germany, 4Clinic of Orthopaedic Surgery, Technical University Munich, Munich, Germany, 55 Department of Computer Science, Technical University Munich, Munich, Germany

Despite its strong relevance in metabolism, non-invasive measurement of adipocyte size remains an unmet need. High b-value DW-MRS has been previously applied to probe diffusion restriction effects of intramyocellular lipids or brown adipocytes using preclinical systems with strong gradient systems. However, probing diffusion restriction in large lipid droplets on a clinical system remains a major challenge. The present work proposes a methodology to probe lipid droplet sizes with high b-value long diffusion time DW-MRS. The method was examined with simulations, validated in phantoms and tested to estimate bone marrow adipocyte size in the tibia of healthy subjects.

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