Abstract #0374

Musculoskeletal Lipid Compartments Separation and Quantification by High-Resolution Metabolite Cycling Magnetic Resonance Spectroscopic Imaging at 3 T

Ahmad Alhulail¹, Pingyu Xia¹, Xiaopeng Zhou¹, M. Albert Thomas², Ulrike Dydak^1,3, and Uzay E Emir^1,4

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Radiology, University of California Los Angeles, Los Angeles, CA, United States, ³Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ⁴Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States

A fast and high-resolution density-weighted concentric ring trajectory metabolite cycling MRSI sequence was implemented to generate simultaneous lipid- and water-only spectra within a short scan time (~3 min) at 3T, and compared to Dixon MRI. LCModel was used to fit the peaks of intramyocellular and extramyocellular lipids that were used to generate separate high-resolution maps for each of these lipid compartments. In addition, the proposed MRSI sequence showed higher sensitivity by sampling lipids at areas that Dixon failed to detect any lipid signal.

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