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Abstract #0374

Musculoskeletal Lipid Compartments Separation and Quantification by High-Resolution Metabolite Cycling Magnetic Resonance Spectroscopic Imaging at 3 T

Ahmad Alhulail1, Pingyu Xia1, Xiaopeng Zhou1, M. Albert Thomas2, Ulrike Dydak1,3, and Uzay E Emir1,4

1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Department of Radiology, University of California Los Angeles, Los Angeles, CA, United States, 3Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 4Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States

A fast and high-resolution density-weighted concentric ring trajectory metabolite cycling MRSI sequence was implemented to generate simultaneous lipid- and water-only spectra within a short scan time (~3 min) at 3T, and compared to Dixon MRI. LCModel was used to fit the peaks of intramyocellular and extramyocellular lipids that were used to generate separate high-resolution maps for each of these lipid compartments. In addition, the proposed MRSI sequence showed higher sensitivity by sampling lipids at areas that Dixon failed to detect any lipid signal.

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