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Abstract #0381

New insights into the development of white matter microstructure across childhood and adolescence from ultra-strong gradients

Sila Genc1,2,3, Chantal Tax2, Erika Raven2, Maxime Chamberland2, Greg Parker2, and Derek K Jones2,4

1Developmental Imaging, Murdoch Children's Research Institute, Parkville, Australia, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 3Department of Paediatrics, University of Melbourne, Parkville, Australia, 4School of Psychology, Australian Catholic University, Melbourne, Australia

Recent advancements in diffusion-weighted imaging analysis techniques, such as fixel-based analysis (FBA), have improved our understanding of fibre-specific patterns of white matter development over childhood. Here, we investigate differential patterns of fibre properties with age and sex, using multiple b-value sampling schemes. The body of the corpus callosum and cingulum undergo significant development over the ages of 8-18, and FBA was robust to these patterns across sampling schemes. However, apparent fibre density (AFD) may be overestimated in clinical sampling schemes for older children, suggesting that higher b-values may improve AFD estimation in emerging complex fibre configurations developing with age.

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