Meeting Banner
Abstract #0382

White matter fibrography of the extremely preterm brain: longitudinal connectome changes from childhood to adolescence.

Ryan McNaughton1, Hernan Jara1, Mina Botros1, Baiyu Zhou1, Stephan W. Anderson2, Osamu Sakai2, Edward Sung2, Robert M. Joseph1, Karl Kuban2, and Michael T. O'Shea3

1Boston University, Boston, MA, United States, 2Boston University Medical Center, Boston, MA, United States, 3University of North Carolina at Chapel Hill Medical Center, Chapel Hill, NC, United States

Purpose: To study comparatively and longitudinally the connectome changes from childhood (age 10 years) to adolescence (age 15 years) using white matter fibrography (WMF). Methods: WMF was used to generate the connectomes of 9 extremely preterm born individuals using MRIs obtained at ages 10 and 15 years. Results: The most noticeable connectome change was a marked increase in the fiber density accompanied by fiber thinning. Conclusion: As anticipated, WMF connectomics of the extremely preterm brain demonstrate clearly observable WM architectural changes from 10 to 15 years of age from sparse fiber-thick to dense fiber-thin.

This abstract and the presentation materials are available to members only; a login is required.

Join Here