Abstract #0382

White matter fibrography of the extremely preterm brain: longitudinal connectome changes from childhood to adolescence.

Ryan McNaughton¹, Hernan Jara¹, Mina Botros¹, Baiyu Zhou¹, Stephan W. Anderson², Osamu Sakai², Edward Sung², Robert M. Joseph¹, Karl Kuban², and Michael T. O'Shea³

¹Boston University, Boston, MA, United States, ²Boston University Medical Center, Boston, MA, United States, ³University of North Carolina at Chapel Hill Medical Center, Chapel Hill, NC, United States

Purpose: To study comparatively and longitudinally the connectome changes from childhood (age 10 years) to adolescence (age 15 years) using white matter fibrography (WMF). Methods: WMF was used to generate the connectomes of 9 extremely preterm born individuals using MRIs obtained at ages 10 and 15 years. Results: The most noticeable connectome change was a marked increase in the fiber density accompanied by fiber thinning. Conclusion: As anticipated, WMF connectomics of the extremely preterm brain demonstrate clearly observable WM architectural changes from 10 to 15 years of age from sparse fiber-thick to dense fiber-thin.

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