Abstract #0390

To discriminate glioblastoma from solitary brain metastasis with inflow-based vascular-space-occupancy (iVASO): comparison with dynamic susceptibility contrast MR imaging

Xiaodan Li¹, Danni Wang², Shukun Liao^1,3, Liuji Guo¹, Yingjie Mei⁴, Xiang Xiao¹, Xiaomin Liu¹, Jun Hua^5,6, Jay J Pillai^7,8, Yikai Xu¹, and Yuankui Wu^1,5,6

¹Department of Medical Imaging, Nanfang hospital, Southern Medical University, Guangzhou, China, ²School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ³Division of CT & MR, Radiology Department, First Affiliated Hospital of Gannan Medical University, Ganzhou, China, ⁴Philips Healthcare, Guangzhou, China, ⁵Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD, United States, ⁸Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Accurate differentiation between GBM and SBM is of vital importance clinically. DSC-MRI cannot differentiate them accurately using measures derived from tumoral regions. Moreover, DSC-MRI requires gadolinium contrast agent administration. Inflow-based vascular-space-occupancy (iVASO) is a novel perfusion technique without the need for exogenous contrast agents. In this study, the capability of iVASO in differentiating GBM and SBM was investigated and compared with that of DSC-MRI. The results showed that iVASO-based measures within tumoral regions could differentiate them accurately. This suggests that iVASO may be used as an alternative for perfusion study on brain tumor.

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