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Abstract #0390

To discriminate glioblastoma from solitary brain metastasis with inflow-based vascular-space-occupancy (iVASO): comparison with dynamic susceptibility contrast MR imaging

Xiaodan Li1, Danni Wang2, Shukun Liao1,3, Liuji Guo1, Yingjie Mei4, Xiang Xiao1, Xiaomin Liu1, Jun Hua5,6, Jay J Pillai7,8, Yikai Xu1, and Yuankui Wu1,5,6

1Department of Medical Imaging, Nanfang hospital, Southern Medical University, Guangzhou, China, 2School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3Division of CT & MR, Radiology Department, First Affiliated Hospital of Gannan Medical University, Ganzhou, China, 4Philips Healthcare, Guangzhou, China, 5Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD, United States, 8Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Accurate differentiation between GBM and SBM is of vital importance clinically. DSC-MRI cannot differentiate them accurately using measures derived from tumoral regions. Moreover, DSC-MRI requires gadolinium contrast agent administration. Inflow-based vascular-space-occupancy (iVASO) is a novel perfusion technique without the need for exogenous contrast agents. In this study, the capability of iVASO in differentiating GBM and SBM was investigated and compared with that of DSC-MRI. The results showed that iVASO-based measures within tumoral regions could differentiate them accurately. This suggests that iVASO may be used as an alternative for perfusion study on brain tumor.

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