Abstract #0391

MRI-based Oxygen Extraction Fraction and Cerebral Metabolic Rate of Oxygen Mapping in High-Grade Glioma Using a Combined Quantitative Susceptibility Mapping and Quantitative Blood Oxygenation Level-Dependent Approach

Simon Hubertus¹, Sebastian Thomas¹, Junghun Cho², Shun Zhang^3,4, Ilhami Kovanlikaya³, Yi Wang^2,3, and Lothar R. Schad¹

¹Computer Assisted Clincial Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States, ³Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Department of Radiology, Tongji Hospital, Wuhan, China

MRI-based oxygenation mapping would be beneficial for treatment planning of high-grade gliomas. We used dynamic contrast-enhanced imaging and a combined quantitative susceptibility mapping and blood oxygenation level-dependent approach to quantify the oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in 6 patients with glioblastoma multiforme and 2 with anaplastic astrocytoma. Robust reconstruction of physiologically meaningful uniform OEF maps in healthy tissue was achieved and OEF was significantly lower in the tumor compared to the contralateral side. Blood flow was significantly higher in the tumor only for glioblastoma multiforme. CMRO2 showed no significant differences.

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