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Abstract #0392

Investigating the Influence of DSC-MRI Acquisition Methods on the Clinical Application of Percentage Signal Recovery in Brain Tumors

Natenael B Semmineh1, Laura C Bell1, Ashley M Stokes1, Ethan Mathew1, Matthew D Lee2, Jerrold L Boxerman2,3, and C. Chad Quarles1

1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Alpert Medical School Brown University, Providence, RI, United States, 3Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States

Percentage signal recovery (PSR) derived from DSC-MRI has been shown to exhibit unique properties between enhancing malignant lesions, due to T1 and T2* contrast agent leakage effects. Currently there is no consensus on the choice of acquisition protocols to maximize the effectiveness of PSR to differentiate between tumor types. Using a validated DSC-MRI digital reference object we characterize the influence of preload dosing schemes and pulse sequence parameters on PSR. The goal of this study is to leverage the digital reference object to identify the optimal combination of parameters that provide effective PSR difference between GBM, metastasis, and lymphoma.

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