Abstract #0397

T1, T2 relaxometry for tissue cell density quantification in glioma imaging: Exploration study via 11C-methionine PET and its validation via stereotactic tissue sampling

Manabu Kinoshita¹, Masato Uchikoshi^1,2, Souichiro Tateishi³, Shohei Miyazaki³, Mio Sakai³, Tomohiko Ozaki¹, Katsunori Asai¹, Yuya Fujita¹, Takahiro Matsuhashi¹, Yonehiro Kanemura⁴, Eku Shimosegawa⁵, Jun Hatazawa⁵, Shinichi Nakatsuka⁶, Haruhiko Kishima⁷, and Katsuyuki Nakanishi³

¹Neurosurgery, Osaka International Cancer Institute, Osaka, Japan, ²Canon Medical Systems Corporation, Tochigi, Japan, ³Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka, Japan, ⁴Institute for Clinical Research, Osaka National Hospital, Osaka, Japan, ⁵Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan, ⁶Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan, ⁷Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan

In this study, the authors attempted to use T1, T2 relaxometry for predicting tumor cell density within the brain in glioma patients. The study was conducted in two stages, first as an exploratory study comparing T1, T2 relaxometry and 11C-methinonie PET images, and second as a validation study using intraoperative stereo-tactically obtained tissues. The authors were able to identify a range of T1 and T2 relaxation time indicative of high cell density, which finding was confirmed by stereotactic tissue sampling. This technique was further able to create predictive tumor cell density map by T1, T2 relaxometry alone.

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