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Abstract #0400

Free Breathing Isotropic Cardiac Diffusion Tensor MRI of the Left Ventricle Using M2-gSlider: Unfolding the Fiber Architecture of the Human Heart

Christopher Nguyen1,2,3, Timothy G Reese3,4, Congyu Liao3,4, William J Kostis5, Marcel P Jackowski6, Kawin Setsompop3,4, and Choukri Mekkaoui3,4

1Department of Medicine, Harvard Medical School, Charlestown, MA, United States, 2Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, United States, 3Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Department of Radiology, Harvard Medical School, Charlestown, MA, United States, 5Cardiovascular Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States, 6Department of Computer Science, University of São Paulo, São Paulo, Brazil

Free breathing isotropic cardiac diffusion tensor MRI (DT-MRI) of the entire left ventricle was achieved by combining two recently-developed technologies: second moment (M2) motion compensated spin echo encoding and generalized slice dithered enhanced resolution (gSlider). M2-gSlider can address cardiac motion-induced signal loss under free breathing and can achieve isotropic spatial resolution of 2.5 mm. With spatial resolution three times that of conventional cardiac DT-MRI, the precision of tractography-based indices can be improved. Furthermore, isotropic acquisition eases the interpretation of myocardial fiber architecture including in an “unfolded” representation, depicting both circumferential and longitudinal microstructure in a planar format.

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