Abstract #0400

Free Breathing Isotropic Cardiac Diffusion Tensor MRI of the Left Ventricle Using M2-gSlider: Unfolding the Fiber Architecture of the Human Heart

Christopher Nguyen^1,2,3, Timothy G Reese^3,4, Congyu Liao^3,4, William J Kostis⁵, Marcel P Jackowski⁶, Kawin Setsompop^3,4, and Choukri Mekkaoui^3,4

¹Department of Medicine, Harvard Medical School, Charlestown, MA, United States, ²Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, United States, ³Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Radiology, Harvard Medical School, Charlestown, MA, United States, ⁵Cardiovascular Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States, ⁶Department of Computer Science, University of São Paulo, São Paulo, Brazil

Free breathing isotropic cardiac diffusion tensor MRI (DT-MRI) of the entire left ventricle was achieved by combining two recently-developed technologies: second moment (M2) motion compensated spin echo encoding and generalized slice dithered enhanced resolution (gSlider). M2-gSlider can address cardiac motion-induced signal loss under free breathing and can achieve isotropic spatial resolution of 2.5 mm. With spatial resolution three times that of conventional cardiac DT-MRI, the precision of tractography-based indices can be improved. Furthermore, isotropic acquisition eases the interpretation of myocardial fiber architecture including in an “unfolded” representation, depicting both circumferential and longitudinal microstructure in a planar format.

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