Abstract #0406

Magnetic susceptibility and T2* of myocardial reperfusion injury at 3 and 7 T

Brianna F. Moon¹, Srikant Kamesh Iyer, PhD², Nicholas J. Josselyn³, Akito Imai, MD⁴, Keitaro Okamoto, MD⁴, Yoshiaki Saito, MD⁴, James J. Pilla, PhD², Joseph H. Gorman III, MD⁴, Robert C. Gorman, MD⁴, Giovanni Ferrari, PhD⁵, Yuchi Han, MD⁶, Harold Litt, MD-PhD², and Walter R. Witschey, PhD^1,2

¹Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Physics and Astronomy, Wheaton College, Norton, MA, United States, ⁴Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁵Surgery, Columbia University, New York City, NY, United States, ⁶Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Intramyocardial hemorrhage is a frequent complication of acute myocardial infarction (MI) after reperfusion therapy. This study investigated the relationship between T2* and susceptibility and how they are affected by magnetic field strength. We compare cardiac quantitative susceptibility mapping (QSM) and T2* at 3 and 7 T and demonstrate improved detection of hemorrhage and infarct regions at 7 T in a large animal model correlating with infarct pathophysiology.

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