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Abstract #0406

Magnetic susceptibility and T2* of myocardial reperfusion injury at 3 and 7 T

Brianna F. Moon1, Srikant Kamesh Iyer, PhD2, Nicholas J. Josselyn3, Akito Imai, MD4, Keitaro Okamoto, MD4, Yoshiaki Saito, MD4, James J. Pilla, PhD2, Joseph H. Gorman III, MD4, Robert C. Gorman, MD4, Giovanni Ferrari, PhD5, Yuchi Han, MD6, Harold Litt, MD-PhD2, and Walter R. Witschey, PhD1,2

1Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Physics and Astronomy, Wheaton College, Norton, MA, United States, 4Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 5Surgery, Columbia University, New York City, NY, United States, 6Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Intramyocardial hemorrhage is a frequent complication of acute myocardial infarction (MI) after reperfusion therapy. This study investigated the relationship between T2* and susceptibility and how they are affected by magnetic field strength. We compare cardiac quantitative susceptibility mapping (QSM) and T2* at 3 and 7 T and demonstrate improved detection of hemorrhage and infarct regions at 7 T in a large animal model correlating with infarct pathophysiology.

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